Cancer research is still pushing scientific boundaries and new developments and insights are entering the clinic at increasing pace. Most of the clinical successes come from our understanding of basic processes that govern cancer initiation and progression, including signal transduction. Consequently, we see that especially inhibitors to signaling molecules, in particular kinases, are entering the clinic very rapidly. Therefore, the molecular mechanisms by which signals are received by cells, transduced towards the proper targets and integrated into a biological response are amongst the most-studied areas in modern biology. In this Joint FEBS/EMBO Lecture Course on Spetses, we are bringing together a number of true experts in the field from basic and translational oncology. This course will cover signaling by various pathways (PI3K, WNT, RAS/RAF) but also DNA damage and protein degradation signaling. We will also cover the consequences of pathway deregulation for cellular processes like metabolism and damage repair. Finally, the application or translation of this knowledge into the clinic will be discussed by the speakers.
Registration and abstract submission: April 1, 2024
Organizers: Boudewijn Burgering, with Co-organizer René Medema
5–12 September 2024
Spetses Island, Greece
Molecular mechanisms of ageing and regeneration: from hydra to humans
The Joint FEBS/EMBO Lecture Course ‘Molecular mechanisms of ageing and regeneration: from hydra to humans’ is part of a series of Summer Schools with a 50-year tradition on the wonderful island of Spetses, Greece. It brings together leaders in the fields of ageing and regeneration with early-stage researchers, i.e. PhD students and postdocs. The meeting combines lectures, discussion groups, poster sessions, tutorials under the olive trees or on the beach, and common dinners. The intense nature of the course creates a familiar and inspiring atmosphere and fosters interactions between participants and speakers. It thus creates a unique training and networking opportunity.
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Organizers: Christoph Englert, Tatjana Piotrowski
8–11 September 2024
Protein Termini 2024: from insight to impact
The past decade has seen a broad increase in the understanding that protein function is regulated by co- and post-translational modification of their N- and C-termini. Active research in this field is expanding, including in mechanistic understanding of protein modification, in technologies for examining protein termini and in identification of routes by which protein terminal modifications can be exploited for beneficial purposes. This FEBS Workshop will bring together established expertise in the field with new contributors, and will highlight the opportunities to capitalize on knowledge of protein termini for translation into novel methodologies, therapeutics and agri-tech solutions. Session topics will include ‘Structural and biochemical characterization of protein termini’, ‘New insights into N-terminal processing’, ‘Protein C-termini’, ‘Advances in methodology’, ‘Physiological impact of protein terminal modification’ and ‘Exploiting protein termini’.
Website under preparation.
Organizers: Emily Flashman, Francesco Licausi, Cheol-sang Hwang, Carmela Giglione
16–20 September 2024
Mitochondria in life, death and disease
Mitochondrial research has advanced significantly over the last decade due to the development of new techniques that allow the investigation of mitochondrial functions from new angles. This Joint FEBS/EMBO Lecture Course will cover diverse and prevalent topics related to mitochondrial biology, including I) mitochondrial biogenesis and the role of mitochondria in the control of cellular metabolism, II) mitochondrial dynamics and organellar quality control, III) mitochondrial communication with the cell with a focus on membrane contact sites, and IV) engineering of mitochondrial functions through the development of novel tools to study and functionally manipulate these complex organelles.
Applications deadline: June 1, 2024
Website under preparation. Sign up for alerts here.
Fish Immunology: molecular and evolutionary perspectives
Fish represent a huge biological community that plays a key role in the equilibrium of the planet’s aquatic systems. The aim of this FEBS Advanced Lecture course is to provide new knowledge on the functioning and evolution of the fish immune system, to highlight how the fish immune system tackles bacterial, viral and parasitic infections, and to explore the role of ecological and environmental constraints affecting fish immunity. The molecular, genetic and functional properties of the fish immune system will be discussed in the view of how to study host–pathogen interactions at the molecular level and to unravel the role of evolutionary and ecological processes in shaping the fish immune system. A particular aspect will be the impact of anthropogenic stressors like climate change and aquatic pollution on fish immunity, and its impact on managing infectious diseases in aquaculture.
Website under preparation.
Organizers: Joachim Frey
28–31 October 2024
5th Danube Conference on Epigenetics
After last year’s success, the FEBS Advanced Lecture Course: Danube Conference on Epigenetics will return in 2024 for the 5th time. The conference will bring together scientists to discuss a range of topics in the field of epigenetics: from transcriptional regulation, through chromatin modifications, nuclear architecture, transgenerational inheritance and metabolism to DNA methylation. Lectures by leading experts in the field will be followed by poster sessions in a relaxed atmosphere. In addition, this year’s program will again feature a dedicated hands-on session on “How to write better scientific papers”, with a specific focus on data visualization. After the exciting sessions, evenings will be shared with new and old friends during social events, ideal for interacting one-on-one with invited speakers. If you wish to immerse yourself in the full spectrum of epigenetics in a friendly atmosphere, then join us in Budapest between 28–31 October 2024!