This FEBS Advanced Lecture Course will cover all  fields related to the study of  the family of poly(ADP-ribose) polymerases (PARPs), from basic molecular and physiological studies to applied clinical research with an explicit aim to cover drug development. The different sessions are organized in a way that facilitates interaction between young researchers and senior scientists. The meeting is expected to host ~100 participants encompassing scientists engaged in drug chemistry, structural biology, biochemistry, DNA damage response, animal and human studies.

Organizers: Andreja Mikos, Ivan Matic

Deadline for applications: 20 March 2023

This course addresses the mechanobiology community and aims at offering a comprehensive view on advanced approaches to measure and quantify the mechanical properties of biological materials at different scales, from molecules to cells and tissues. It will include scientific lectures, hands-on activity with state-of-the-art instruments, and evening discussions with researchers from university and industrial background. A social event will help cement the cohort of attendees.

Organizers: Massimo Vassalli, Lining Ju

Proteolysis is a critical post-translational modification as every protein encounter a protease in their lifetime, be it signal peptide removal, activation, processing, or degradation. Proteases act in concerted networks to amplify signals, regulate biology and are hypothesized molecular switches and effectors involved in tissue remodeling. The extracellular matrix (ECM) regulates key functions such as cell movement, shape, growth and survival via cell adhesion, cell-ECM, and cell-cell interactions, and some biological functions that are still uncharacterized. We are only beginning to understand the intriguing regulatory aspects of proteases that modulate the ECM and many questions remain.  Specifically, 1- How universal are the auto-feedback mechanisms driven by ECM proteolysis? 2- How does cleaved ECM regulate the initiation and resolution of inflammation and cancer progression? 3- Does aberrant proteolysis dysregulate the resolution of inflammation or it is the ECM that regulate proteolysis?  Our meeting will directly address these questions by inviting several experts from the ECM and proteases and give them an opportunity to discuss where the next decade will take us.

Organizers: Irit Sagi, Antoine Dufour, Nikos Karamanos

This FEBS Advanced Lecture Course / 14th European Summer School on Advanced Proteomics – an internationally renowned educational event – will be held again in Kloster Neustift near Bressanone/Brixen, South Tyrol, Italy. It is designed to provide graduate students and young postdoctoral scientists with insights into state-of-the-art proteomic technologies and applications in the life sciences. One of our main goals is to create an environment that allows young scientists to interact with each other and with experts in the field. Join us for a summer school including lectures by invited speakers, workshops and poster presentations framed by various special activities.

Organizers: Katrin Marcus, Caroline May, Christina Ludwig, Shabaz Mohammed, Jesper V. Olsen

Our FEBS Advanced Lecture Course aims to provide PhD students and postdocs with different backgrounds an adequate introduction into epigenomics and nuclear receptor signaling, and particularly to cross-fertilize these burgeoning fields to better understand disease mechanisms. The interactive program and the idyllic surroundings will facilitate scientific and social networking during workshops, lunch discussions about lecture topics, poster and short talks sessions, afternoon breaks and tutorial dinners.

Organizers: Eckardt Treuter, Karen E. Knudsen, Susanne Mandrup, Nicolas Venteclef

Deadline for applications: 9 May 2023

In this FEBS Advanced Lecture Course we have brought together a unique combination of frontiers in science focusing on the the capacity of numerous proteins and peptides to self-assemble into amyloid fibrils. The course includes introductory and state-of-art lectures with special emphasis on amyloid structures, chaperones in amyloid formation, membrane-less organelles, lipids and membranes in amyloid formation, functional amyloids, and pathology of amyloids. In the evening lectures, the different topics will be discussed in an integrative manner. Young researchers will have ample opportunity to meet and to discuss basic and emerging topics with the lecturers as social interactions are an important aspect of the meeting.

Organizers: Bernd Helms, Sheena Radford, Stefan Rüdiger

Deadline for applications: 1 May 2023

Over the past 20 years metabolomics has evolved into a powerful tool allowing the investigation of hundreds to low thousands of metabolites from many areas of metabolism and can be applied across the biological sciences to investigate cellular organisms from microbes to humans and plants. In this FEBS Practical Course we will combine lectures, hands-on laboratory sessions, computer workshops, and interactive group activities to introduce you to applying metabolomics in your research.

Organizers: Warwick Dunn ([email protected]), Cate Winder

This FEBS Combined Practical & Lecture Course is intended to bring together computational and experimental enzymologists who will give comprehensive lectures towards understanding and engineering enzyme catalysis. Hands-on practical sessions will be focused on how to use state-of-the-art software and web servers to understand carefully chosen phenomena in this research field. Experimental researchers will give lectures on how these in silico approaches have successfully helped them with solving problems in their research related to understanding and engineering enzyme catalysis

Organizers: Aleksandra Maršavelski, Tomica Hrenar, Jiří Damborský, Outi Lampela, Tiila-Riikka Kiema, Rikkert Wierenga