Close to 40% of human genes encode long and small non-coding RNA, many of which are conserved throughout evolution. They perform many essential functions in germ and somatic cells, ranging from the suppression of retrotransposons to fine-tuning gene expression. Yet the molecular mechanisms underlying these processes remain incompletely understood. The goal of this meeting is two-fold. One is to review recent advances in studying non-coding RNA biology, from biosynthesis to function. The second is to discuss the use of therapeutic non-coding RNAs (including antisense, small interfering, and CRISPR RNAs) as tools to correct faulty gene expression in human disease.

Image courtesy of the National Human Genome Research Institute.

Location: Chania, Greece

Organizers: Andrei Thomas-Tikhonenko