FEBS Press Awards
The FEBS Journal Richard Perham Prize 2017
The FEBS Journal Richard Perham Prize is awarded to the first author of the best paper by a graduate student or young post doc (no more than 3 years from the date of award of the PhD degree when the paper is submitted) published in the journal during the previous calendar year. The choice of prizewinner is made by the Editorial Board of the journal. The prize consists of a personal gift of €1000 plus an invitation to present the work in a plenary lecture at the annual FEBS Congress.
Death receptor 3 (DR3) and its ligand, TL1A, are members of the tumour necrosis factor receptor superfamily (TNFRSF) and TNF ligand superfamily (TNFSF), respectively. TL1A–DR3 signalling has a key role in the development of autoimmune and inflammatory diseases. Intriguingly, DR3-mediated signalling also increases the number of regulatory T cells to counteract inflammatory processes. Despite the prominence of TL1A–DR3 signalling in inflammation, the mechanism by which TL1A activates DR3 remained enigmatic. In the prize-winning work, Bittner and colleagues demonstrated that the soluble, trimeric form of TL1A is sufficient to trigger DR3 activation and subsequent internalisation. Further oligomerisation of TL1A does not enhance its signalling activity. Given the importance of the TL1A–DR3 interaction in autoimmune and inflammatory diseases, these findings provide an essential foundation for future therapeutic exploitation of this pathway.
The FEBS Letters Award 2016
Every other year, FEBS Letters offers a prestigious prize of €10,000 to the senior author of an outstanding Research Letter published in FEBS Letters during the previous two calendar years. The criteria for this selection are based on functional insight, depth of experimental analysis and broadness of impact.
FEBS Letters is happy to announce that the FEBS Letters Award 2016 is presented jointly to Kim Nasmyth (University of Oxford, UK; pictured furthest right) and Jan Löwe (MRC, Cambridge, UK; pictured near right) for their outstanding paper:
Structure and function of cohesin’s Scc3/SA regulatory subunit
Maurici B. Roig, Jan Löwe, Kok-Lung Chan, Frédéric Beckouët, Jean Metson and Kim Nasmyth
FEBS Letters 588, 3692–3702 (2014)
Sister chromatids are held together by the cohesin ring structure, which is created through association of a kleisin subunit (Scc1/Rad21) with ATPase heads of Smc1/Smc3 heterodimers. Scc3 is the most important of cohesin’s regulatory subunits. Nasmyth/Löwe and colleagues have now solved the crystal structure of the yeast Scc3 subunit, analyzed its interaction with Scc1 and determined the key residues for cohesin’s release from chromatin. Using live-cell studies they suggest that Scc3 can turn over more rapidly than the 'core' cohesin subunits, and is responsible for maintaining as well as establishing cohesion. Scc3 turns over in G2/M while maintaining cohesin’s association with chromosomes and it promotes de-acetylation of Smc3 upon Scc1 cleavage. These findings are expected to provide insight into a broad range of molecular events related to chromatin organization and regulation.
The winning article is selected by a special Award Committee, formed by appointed members of the Editorial Board, plus one external member. The Award Committee members were: Laszlo Nagy (Orlando) Chair, Miguel De la Rosa (Seville), Irene Diaz Moreno (Seville), Wilfried Ellmeier (Vienna), and Daniela Ruffell (Editorial Office).
Dr Jan Löwe will deliver a plenary lecture about his work at the FEBS Congress in Jerusalem, Israel in September 2017, where he will be officially presented with the prize on behalf of both winners.
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For details on all FEBS awards, click here.