The FEBS Journal Special Issue on Proteases and Proteolysis in Health and Disease is out!
In this Special Issue of The FEBS Journal, we present eleven free reviews from experts in the field of proteases and proteolysis. These reviews cover important and emerging topics in this diverse field – from protease deregulation in disease and protease-targeting drug development to the latest methodologies in protease activity measurements.
The issue begins with a comprehensive review on caspases and cell death substrates from Denault and colleagues , followed by three reviews exploring protease deregulation in human disorders. Tanabe and List highlight the roles of type II transmembrane serine proteases in cancer signalling , Reinheckel and colleagues give an overview of the genetic disorders caused by mutations in cathepsin-encoding genes  while Blum and colleagues discuss the involvement of cysteine cathepsin proteases in several deregulated processes in atherosclerosis .
McGowan and colleagues discuss how M1 aminopeptidases can be targeted for drug development against a range of diseases , Steven Verhelst outlines the potential and the challenges for intramembrane proteases as viable drug targets  and O'Donoghue and colleagues discuss how approved proteasome inhibitor drugs can be modified to selectively target pathogenic organisms such as Plasmodium falciparum .
Three reviews cover the latest methods for measuring protease activity in vivo. Drag and colleagues give an overview of the best substrates and inhibitors needed to distinguish individual proteases  while Bogyo and colleagues highlight activity-based probes and their applications for measuring the activities of the proteasome  and the ubiquitin conjugating–deconjugating machinery .
Finally, Sueldo and van der Hoorn close this issue with a look across the plant kingdom and the role of cysteine proteases in programmed cell death in plants .
Special thanks to Matthew Bogyo for coordinating this Special Issue and providing an engaging and thoughtful introduction . We also thank our authors and the referees for their contributions and hope you enjoy reading these reviews as much as we have.
The FEBS Journal Editorial Office