The FEBS Journal Richard Perham Prize 2021
The prize was awarded for the below outstanding paper published by Antonio Barbáchano, Alberto Muñoz and co-authors in The FEBS Journal in 2020. One of the senior authors, Dr Antonio Barbáchano (Instituto de Investigaciones Biomédicas 'Alberto Sols', Spanish National Research Council (CSIC), Madrid, Spain), will present a plenary lecture about this work at the IUBMB–FEBS–PABMB Congress on 9–14 July 2022.
Vitamin D differentially regulates colon stem cells in patient-derived normal and tumor organoids
Asunción Fernández-Barral, Alba Costales-Carrera, Sandra P. Buira, Peter Jung, Gemma Ferrer-Mayorga, María Jesús Larriba, Pilar Bustamante-Madrid, Orlando Domínguez, Francisco X. Real, Laura Guerra-Pastrián, Miguel Lafarga, Damián García-Olmo, Ramón Cantero, Luis Del Peso, Eduard Batlle, Federico Rojo, Alberto Muñoz and Antonio Barbáchano. FEBS J, 2020, 287: 53–72. doi:10.1111/febs.14998
Vitamin D deficiency has been linked to enhanced colorectal cancer (CRC) risk and mortality. Human colonic stem cells – known as crypt stem cells – are essential in gut homeostasis and their alteration is a feature of CRC. Alberto Muñoz, Antonio Barbáchano and colleagues generated a living-biobank of stem-cell-derived normal and tumor colon organoids from CRC patients. They show that vitamin D upregulates stemness-related genes and the undifferentiated phenotype in normal organoids, whereas it induces differentiation in tumor organoids. These findings uncover a regulatory role of vitamin D on crypt stem cells, with relevance to CRC development.
For more information about this award, please see The FEBS Journal Richard Perham Prize