The FEBS Journal Richard Perham Prize 2020
The prize was awarded for the below outstanding paper published by Kazunori Mori and co-authors in The FEBS Journal in 2019. The senior author, Dr Motoko Shibanuma (Showa University School of Pharmacy, Tokyo, Japan), will present a plenary lecture about this work at the 45th FEBS Congress in Ljubljana, Slovenia in July 2021.
A mitochondrial ROS pathway controls matrix metalloproteinase 9 levels and invasive properties in RAS‐activated cancer cells
Kazunori Mori, Tetsu Uchida, Toshihiko Yoshie, Yuko Mizote. Fumihiro Ishikawa, Masato Katsuyama and Motoko Shibanuma
FEBS J, 2019, 286: 459–478. doi:10.1111/febs.14671
Matrix metalloproteinases (MMPs) are a group of tissue‐remodeling enzymes that have been linked to a variety of pathophysiological processes, including cancer metastasis. In this study, the authors provided new insights into the regulation of MMP9. They showed that the molecular adaptor protein HIC‐5 suppresses the activation of NADPH oxidase 4 (NOX4), leading to downregulation of mitochondrial ROS levels, which in turn destabilizes MMP9 mRNA. They further demonstrated that this regulatory axis operates specifically in cancer cells harboring oncogenic mutations in H‐ or K‐ras, potentially unveiling a new therapeutic avenue for cancer therapy based on inhibition of MMPs.
Find more information on the award here: The FEBS Journal Richard Perham Prize