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Published on 21 Mar 2019
The FEBS Journal Richard Perham Prize 2019
The FEBS Journal Richard Perham Prize 2019 was awarded for the below outstanding paper published by the Klinke lab (Department of Chemical and Biomedical Engineering and WVU Cancer Institute, West Virginia University, USA) in The FEBS Journal in 2018. The monetary part of the award will be shared between joint first authors of the paper – Cassidy L. Bland and Christina N. Byrne-Hoffman – and senior author David J. Klinke II will be congratulated on the prize and present a plenary lecture about this work at the 44th FEBS Congress in Krakow, Poland in July 2019.
Exosomes derived from B16F0 melanoma cells alter the transcriptome of cytotoxic T cells that impacts mitochondrial respiration
Cassidy L. Bland, Christina N. Byrne‐Hoffman, Audry Fernandez, Stephanie L. Rellick, Wentao Deng and David J. Klinke II
Exosomes are emerging as important messengers for heterotypic cell communication within the tumour microenvironment. To understand how tumour‐derived exosomes potentially affect immune cell function, Klinke and colleagues quantified how the coding and noncoding RNA payload within exosomes derived from B16F0 melanoma cells altered the transcriptome in recipient CTLL2 cytotoxic T cells. Their results suggested that the exosomal payload altered mitochondrial respiration, epigenetic regulation, and Notch signalling within cytotoxic T cells. However, exosomal miRNA did not downregulate target mRNA levels.
For more information on the award, click here: The FEBS Journal Richard Perham Prize