FEBS Letters Special Issues 2020

Microbes and Complement

Edited by Hanna Jarva and Seppo Meri

Complement, as part of both the innate and adaptive immune systems, plays a central role in our defense against infections. This Special Issue of FEBS Letters contains 14 articles devoted to the role of complement in microbial infections and is particularly timely because the SARS‐CoV‐2 pandemic has dramatically increased the public interest in microbes and in preventing infections.

Sphingolipid Biology

Edited by Giuseppe D’Angelo, Christopher Clarke and Liana C. Silva

Sphingolipids are a fundamental class of molecules embedded in membrane bilayers. This Special Issue explores their biological functions, the metabolic network of enzymes that control sphingolipid levels, as well as human disease derived from defects in the production or breakdown of sphingolipids.

Diversity of Structure and Function of ABC Transporters

Edited by Ute A. Hellmich, Amro Hamdoun, Karl Kuchler and Gergely Szakacs

ABC proteins operate as directional and bidirectional membrane transporters, as channels, receptors and conductance regulators. As such, they are major players in cancer, genetic diseases, anti-infective drug resistance, and crop science – just to name a few. Making sense of this diversity of functions and mechanisms serves as the overarching theme for this Special Issue of FEBS Letters.

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