Postdoctoral Research Associate, Northeastern University, Boston, United States
The Engen Laboratory at Northeastern University seeks an enthusiastic postdoctoral researcher to study PROTACs, the recently emerged modality for pharmacological treatment of diseases. The project will probe the structural and dynamic properties of the ternary complex formed between PROTAC, target protein, and E3 ligase, and how these interactions are key for the efficiency of the ubiquitin transfer from ligase to protein of interest.
Funding: This fully-funded appointment is for 2 years, but could extend beyond that in some circumstances.
Candidate profile: The candidate should have strong problem-solving skills and be highly motivated. The candidate must have a Ph.D. in chemistry, biochemistry, molecular biology, structural biology or a closely-related field. Previous experience with PROTACs, E3 ligases, ubiquitin-mediated degradation, or similar fields of study is necessary, as is a keen interest in proteins and how they function. Previous experience with structural analysis (x-ray, NMR or cryoEM) of proteins is preferred. A willingness to learn hydrogen/deuterium exchange mass spectrometry and other structural methods to augment their protein knowledge will be needed. Demonstrated proficiency in protein chemistry and protein biophysical analysis are preferred. Technical expertise in modern chromatography methodologies and techniques, good computer skills, and data analysis experience are all desirable. The best candidates will have excellent communication, organization, and time management skills.
Contact and application: Candidates should contact Prof John Engen directly with their CV and a brief cover letter describing their background and specific research interests. Earliest start date is July 1, 2022.
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