New Minireview Series on Matrix Pathobiology from The FEBS Journal
This Minireview Series from The FEBS Journal presents three timely reviews covering pathological roles for key extracellular matrix proteins. These minireviews highlight the latest research on proteoglycans and heparanase, with an emphasis on their roles and regulation in cancer.
Renato Iozzo and colleagues review the latest studies on the leucine-rich proteoglycans, biglycan and decorin, and their importance in inflammation and autophagy in cancer . Nikos Karamanos and colleagues highlight the roles of syndecans in cell adhesion and migration, and their emergence as prognostic tools for cancer progression . Ralph Sanderson and colleagues discuss the recently discovered regulatory mechanisms of heparanase in inflammation, autophagy and cancer progression and the potential use of heparanase inhibitors in cancer therapy .
Special thanks to Nikos Karamanos for coordinating this Minireview Series and for his compelling introduction. We also thank our authors and referees for their contributions, and hope you enjoy reading these reviews.
The FEBS Journal Editorial Office